This covered the indication of acute bronchitis and included the typical symptoms such as cough, sputum (phlegm) production, shortness of breath, and wheezing related to the obstruction of inflamed airways. Hedera helix preparations (ivy leaf extracts) are worldwide marketed for the treatment of different diseases of the respiratory tract system and include catarrh of the respiratory passages; symptomatic treatment of chronic inflammatory bronchial illnesses; and acute inflammations of the respiratory tract accompanied by coughing (HMPC Assessment) [1]. Ivy leaf extract is a traditional ingredient that has been used for centuries to support bronchial health. Two galenical formulations of an ivy herbal extract, syrup and cough drops, were tested for their efficacy and safety in the paediatric treatment of cough and bronchitis in two independent open, non-interventional studies with identical design. Non-drowsy, sugar-free, alcohol-free, no added coloring with pleasant natural blackcurrant flavor. $16.39$16.39 ($3.21/Fl Oz) FREE Shipping. Material and Methods. At entry visit, duration of symptoms was assessed as well (Table 3). Soothing syrup provides relief from occasional irritation; Breathe Easy with Bronchial Soothe! Review articles are excluded from this waiver policy. The physician selected the patients for whom the diagnosis enabled them to be included into the study and to be treated with the abovementioned prescriptions. Sieben et al. Essentially, all captured data are calculated as frequency distributions and descriptive analysis (e.g., averages, medians, standard deviations, minimums, and maximums). Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. Criteria for exclusion of the documentation were as follows: known hypersensitivity to the active ingredients, treatment with the medications in the last two weeks before study entry, participation in another trial in the same time, and legal incapacity. Results of trials with different extracts are only valid for the tested preparation but not for the tested plant [15]. Further, cough-associated sleeping disorders improved more in the EA 575® group. The average age was 44.3 years for the EA 575® group and 49.1 years for the ACC group. In total, 139 data sets were analysed: 118 from the EA 575® group and 21 from the ACC group. The following clinical findings were documented during both visits by the physicians in accordance with the Bronchitis Severity Score (BSS) [16] by a 5-stage assessment: coughing fits, sputum, rales/rhonchi, and dyspnoea during coughing. Relevant concomitant diseases and treatments. You may need to read it … Product: Cofif Plus Syrup. This results in 118 × 7.48 = 883 patient days. These positive results for the herbal medication correspond to the pharmacological actions of ivy. During the study, two unwanted events occurred. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bro… Acute cough is mainly caused by viral infection [5–8]. Significant improvement in each of the symptoms from entry visit to final visit (, Assessment of the Efficacy and Safety of Ivy Leaf (, Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland, Evidence-Based Complementary and Alternative Medicine, Acute bronchitis, caused by bacterial infection (ICD-10: J20.0-J20.2) [, Acute bronchitis, caused by viral infection (ICD-10: J20.3-J20.7), Other acute inflammation of the respiratory tract accompanied with cough, The average duration of symptoms at entry visit (days), Concomitant infections and other diseases, None (N; % of patient within treatment group), R. P. Wenzel and A. Nat Med 1999;14:28–33. Acute bronchitis affects approximately 5% of adults annually, with a higher incidence observed during winter and fall than in summer and spring [3, 4]. Patients themselves rated the following symptoms that were queried by the physician: 5-staged-score for coughing intensity, chest pain during coughing, dyspnoea during coughing, cough-related sleep disturbances, and possibility to cough-up mucus and 4-staged-score for number of coughing fits during daytime. Since data were incomplete for this patient, it was not considered in the overall study assessment. It is an efficient and natural remedy for adult and children. Results. 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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the United States, acute bronchitis is the ninth most common illness among outpatients, as reported by physicians [9]. A. Fowler, “Acute bronchitis,”, V. Benson and M. A. Marano, “Current estimates from the national health interview survey, 1995,”, J. Macfarlane, “Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community,”, T. C. Medici, M. Häcki, and M. V. Spiegel, “Spiegel MV. Further, the severity of the disease was rated by a 7-stage-score and coughing quality (auscultation) by a 3-stage-score. EA 575® is effectively independent of the indication or concomitant disease. oz. IVY leaf. One patient reported at the final visit to have “discontinued treatment” after 8 days and switched to ACC due to lack of efficacy. One patient reported diarrhea after she had used EA 575® for two days, and after discontinuing of the medication, the patient had recovered. At entry visit, all clinical assessments including coughing fits, sputum, dyspnoea, rales, severity of the diseases, and coughing quality were rated with moderate intensity in both groups. Coferb Cough Syrup. Acute bronchitis is a clinical term implying a self-limited inflammation of the large airways of the lung that is characterized by cough without pneumonia. Furthermore bronchial muscle cells reduce under β2-stimulating conditions the intracellular Ca2+ level. The criteria for inclusion of the patient’s data in the study documentation were as follows: signing the informed consent, age six years and older, and having symptoms of an acute bronchitis accompanied with productive cough for at least 3 days for whom a therapy with EA 575® or ACC is indicated according to the physician. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. Material and Methods. Maty's Organic Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. Product Name: Cofloz Ivy Leaf Cough Syp 120ml Product Form: Syrup Pack Size: 120ml Marketed By: Abbott Laboratories (Pakistan) Ltd Generic Category: Anti-Tussive Ingredients: Ivy Leaf Extract Alternative & Herbal Products. The exclusive ivy extract in Bronchial Soothe provides herbal support for optimal lung and bronchial passageway health. https://www.blackmores.com.au/.../ivy-leaf-for-cough-relief In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. Subgroup evaluation was performed within the EA 575® group regarding indication at inclusion into the study and concomitant disease or infection. Most of these studies have been performed as uncontrolled, open postmarketing studies, some studies in a randomized placebo-controlled design, and some in a reference-controlled design. – Non GMO Sustainably Sourced Vegetarian, Zarbee's Naturals Baby Cough Syrup with Agave & Thyme, Natural Cherry Flavor, 2 Ounce Bottle, Robitussin Naturals Cough Relief & Immune Health Syrup 8.3oz with Honey, Ivy Leaf & Zinc. Sydler Remedies Private Limited - Category: Pharma & Supplements. Furthermore, concomitant diseases were treated with different antibiotics or other treatment which also might have an impact on the treatment outcome for the acute bronchitis. There's a problem loading this menu right now. The physician was totally free in his or her decisions of therapy. However, there are other pharmacologic treatments for impaired mucous secretion clearance including agents such as isotonic saline and acetylcysteine (also known as N-acetylcysteine (NAC)). Hedera helix. Cough and fever are the most common symptoms of acute bronchitis in children. Sign up here as a reviewer to help fast-track new submissions. from a wet cough; active substance: ivy leaf extract; syrup; country of production: Ukraine It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk-benefit ratio. The severity of the disease and the calculated BSS showed the same result (Figure 2). PROSPAN ® Cough Syrup with ivy leaf offers reliable help with the excessive formation of thick mucous and coughs associated with colds.. An exclusive extraction method and absolute precision in production ensure the quality of the dried ivy leaf extract that makes PROSPAN® such an effective and safe remedy. Diseases with the leading symptom “cough” are economically relevant as respiratory diseases are the most common reason for working incapacity and affect the quality of patient’s life [2]. English ivy exhibits antiviral, antimycotic, and anthelmintic and effects and some studies indicate that the I was prescribed ivy leaf extract for my (quite heavy) cough. Early research shows that taking a cough syrup containing English ivy leaf might improve coughing and breathing in children and adults with different types of bronchitis. Ivy leaves (hederae helicis folium) exert an expectorant and antispasmodic action on the respiratory tract [1]. It is characterized by a persistent cough which can be productive or dry. Cough syrup (Prospan; Panoto-s; Athos; Abrilar) containing English ivy leaf extract is POSSIBLY SAFE when taken by mouth three times daily for 1 week. The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575® by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. Physicians judged the tolerability as “very good” and “good” with 99.1% for the EA 575® group and 95.2% for the ACC group. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bronchial Health, Supports Healthy Mucous Membranes, Effective for Adults and Children. 2016-01555). NAC hydrolyzes the disulfide bonds of mucus proteins to decrease the mucus viscosity, thereby facilitating its clearance [22]. Ivy leaf is a source of saponins, sterols, flavonoids. At the final visit after seven days of treatment, there was a comparable improvement in both groups for all assessments except dyspnoea and number of cough attacks which showed a higher improvement in the EA 575® group compared with ACC. Your recently viewed items and featured recommendations, Select the department you want to search in, All customers get FREE Shipping on orders over $25 shipped by Amazon, Try our simple and soothing honey cough syrup, Zarbee's Naturals Cough Syrup + Mucus Nighttime with Melatonin, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals Cough Syrup* + Mucus, Natural Honey Lemon Flavor, 8 Ounce Bottle, Zarbee's Naturals 96% Honey Cough Soothers + Mucus with Ivy Leaf Extract, Lemon Menthol Flavor, 14 Count. Before recruitment, the study procedure was explained to the subjects in detail, after which they signed consent forms. An interim analysis, which was performed 15 months after study start, showed that data of the collected 139 patients were sufficient for an explorative analysis with the group comparison. Introduction: Ivy leaf extract is an essential oil extracted from plant leaves. We start with our proprietary Dark Honey Blend and add English Ivy Leaf extract and Marshmallow Root Extract to soothe irritated throats and help your child clear mucus when they are coughing. Subsequently, treatments were prescribed by the doctor. The results show that there is no evidence that the efficacy differs between both groups. Average weight was 66.1 kg in the EA 575® group and 71.7 kg in the ACC group. Liver disorders. The clinical effects of Hedera helix have been investigated in a total of more than 20 [12–14] clinical studies mostly in children suffering from upper airway infections. Active ingredient: Each 5 ml of syrup contains 35 mg of extract (as dry extract) from ivy leaf (Hedera helix L.) (5 - 7.5 : 1). You’re seeing this ad based on the product’s relevance to your search query. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. In addition, approximately 50% of patients with acute bronchitis report the production of purulent sputum [2]. Acetylcysteine (ACC) was chosen as comparator drug (common mono preparations). Complement Med Res 2005;12(6):328-32. During the final visit, after approximately 1 week, information on the therapy and the course of the symptoms was documented. Within the 139 included patients, only 21 patients were prescribed an acetylcysteine preparation resulting in an unequal group distribution. 24.6% of the subjects from the EA 575® group suffered from acute bronchitis caused by bacterial infection and 19.0% in the ACC group (Table 2). Botanical names: Hedera helix How It Works Although ivy's composition has not been subject to detailed scientific investigations, it is known to contain 5–8% saponins. Product: Cofif Syrup. The present Swiss study investigated the intake of EA 575® and acetylcysteine and confirmed the results from Lang et al. Prospan Chesty Cough Relief - Prospan Australia - Prospan … 13 children belonged to the class group 6–11 years with an average height of 136.0 cm and an average weight of 32.3 kg. Significant improvement in each of the symptoms from the entry visit to final visit (, Average values of physician`s evaluation for severity of disease and calculated BSS score at entry and final visit in both groups comparing the final visit with the entry visit. Directions: Most studies were conducted with preparations containing the ivy leaf dry extract EA575® as active ingredient [12]. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. With regard to duration of symptoms, no significant differences were observed between the treatment groups. The current noninterventional study was performed in 118 patients using EA 575® and 21 patients using ACC for the treatment of acute bronchitis. dried ivy leaf extract 【Botanic Name】Hedera helix L. 【Use Part】Leaf 【Specifications】10%-40% Hederacosides, 3%-20% Hederacoside C, 10:1. Coughing fits was the most common finding. Zarbee's Naturals Children's All in One Nighttime Cough Syrup + Mucus, Throat & Nasal, Natural Grape Flavor, 4 Ounce, Prospan Cough Syrup - 100ml CHESTY Cough Relief & Mucus Relief. CZ and EK are the employees of Max Zeller Söhne AG. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. At the inclusion visit, demographic and anamnestic data as well as the indication and typical complaints were recorded in the case report form. L. Ivy leaf preparations are obtained as dry, liquid and soft extracts by putting the plant material in a solvent (such as ethanol) to dissolve compounds and form a liquid extract. Each patient had the right to terminate the study participation at any time. The study results indicate that ivy leaf extract might be an effective alternative to acetylcysteine with respect to the improvement of respiratory function in children and adults at a slightly better evaluation of efficacy. 22. A previous multicenter study showed that EA 575® exerts mucolytic action equal to acetylcysteine but with better tolerability [23]. All symptoms showed a comparable improvement in the reduction of both groups from baseline to end visit. Two-hundred and sixty-eight children aged 0-12 yr were … The average duration for symptoms at entry visit was 2.341 days in the EA 575® group and 2.33 days in the ACC group. You will always find ivy leaf extract cough that are suitable for your necessities because they come in different sizes and packaging designs. 5 Other constituents in the The evaluation of the individual data on symptoms was only carried out for those patients in whom the symptom was present at the beginning of the study. Ivy is solid at its base, and then it starts to crawl. [12] in children and adults. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. Open trials to assess aspects of safety and efficacy of a combined herbal cough syrup with Ivy and Thyme. In some studies, patients were requested to fill out diaries with daily assessments of, e.g., cough frequency, expectoration, and breathlessness. The research protocol was reviewed and approved by the Independent Ethics Committee, EKOS (Ethikkommission Ostschweiz) on 16.12.2016 (BASEC Nr. For both treatments, the change from the baseline bronchitis severity score (BSS) to the score at day 7 was calculated. Average values of physician’s evaluation comparing the final visit with the entry visit. These effects are attributable, in particular, to the therapeutically important constituents of the ivy leaf extract, which belong to the class of triterpene saponins such as hederacoside C (Figure 1), a marker and an active ingredient of ivy leaf extract [7–10]. Symptoms could last up to 3 days and not longer to assure the acute situation. 2020, Article ID 1910656, 7 pages, 2020. https://doi.org/10.1155/2020/1910656, 1Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, 2CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, 3Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland. The level of significance was α = 0.05. There were 4 different consent forms used in the study depending on the age of the subjects: one consent form for adult subjects, one form for subjects ranging between 14 and 18 years old (signed by the subjects), one form for subjects between ages 11 and 13 years who can already read the document by themselves (signed by the parents), and one form for parents of subjects between 6 and 11 years (signed by parents). Ivy Leaf Cough Syrup Benefits: Natural formula to reduce coughing, soothe airways and to clear mucus and phlegm or effective congestion and cough relief. At the beginning, BSS average was 6.5 points in the EA 575® group and 6.7 points in the group of ACC patients, respectively, showing a moderate impairment for both. Ivy creepers grow up to 30 meters long with a permanent green leaves and numerous aerial roots which help it affix on trees and stones. English ivy leaf extract might cause mild stomach problems.. Not enough is known about the safety of applying English ivy to the skin. Comparable improvement was seen for all symptoms between both groups from the entry to final visit which was statistically significant. No statistical significance was seen between the treatments. Observations of the tolerability were comparable for both products. Ivy leaf is also gaining popularity as a natural cough syrup for kids. Description. * Ivy leaf supports healthy mucosa beginning with the nose, mouth, and throat, and continuing to the bronchial passageways and lungs. 7 children were noted in the class group 11–13 years with an average height of 137.1 cm and an average weight of 37.0 kg. NAC is used as a treatment option in various conditions in which there are problems with clearance of lung mucosal secretions. UNDA - Drosera Plex Cough Syrup - Homeopathic Remedy for Temoporary Relief of Cough - 6.1 fl. Trials with different extracts are only valid for the tested plant ivy leaf extract syrup ]! 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